Dr. Ngozi Ugochukwu
|Professor of Biochemistry||Dept. Office: (850) 599-8420|
Office #: (850) 412-7124
Lab #: (850) 561-2434
Fax #: (850) 561-2388
The main thrust of our research is the use of enzymology and cutting-edge biochemical and gene technology techniques in deciphering the underlying mechanisms in the pathophysiology of chronic metabolic diseases especially diabetes, obesity, congestive heart failure and colon cancer and their unifying link in quest of non-invasive nutritional interventions for effective preventive strategies and therapies. The methodologies are multifaceted involving the ‘omics’: pharmaco/nutrigenomics; transcriptomics (examining the expression level of mRNAs using high thorough-put techniques based on DNA microarray technology); proteomics (in discovery of disease biomarkers) and metabolomics (end-products of gene expression). Integration of all the data obtained from these methodologies give a more complete picture of the status of the organism in the disease state and therefore very valuable at the molecular level.
We are also currently studying the health disparities involved in the infection and mortality of HIV-AIDS patients; various Cancers, Chronic Kidney and Cardio-Metabolic Diseases in Florida Counties.
Selected Publications (with in last 5 years) 1.
Ugochukwu, N.H. and Figgers C.L. (2007) Attenuation of plasma dyslipidemia and oxidative
damage by dietary caloric restriction in streptozotocin-induced diabetic rats. Chemico-Biological
Interactions 169, 32-41.
Mwegoha, W., Mbuya, O.S., Jain, A., Ugochukwu, N.H. and Abazinge, M.D. (2007) Use of
chicken manure extract for biostimulation and enhancement of perchlorate
rhizodegradation in soil and water media. Bioremediation Journal 11, 61-70.3.
Ugochukwu, N.H. and Figgers C.L. (2007) Caloric restriction inhibits up-regulation of
inflammatory cytokines and TNF-α, and activates IL-10 and haptoglobin in the plasma
of streptozotocin-induced diabetic rats. The Journal of Nutritional Biochemistry 18,
Ugochukwu, N.H. and Figgers C.L. (2007) Dietary caloric restriction improves the redox status at
the onset of diabetes in hepatocytes of streptozotocin-induced diabetic rats. Chemico-Biological
Interactions 165, 45-53.5.
Ugochukwu, N.H. and Figgers C.L. (2006) Modulation of the flux patterns in carbohydrate
metabolism in the livers of streptozotocin-induced diabetic rats by dietary caloric restriction.
Pharmacological Research 54, 172-180.6.
Ugochukwu, N. H., Mukes, J. D. and Figgers, C.L. (2006) Ameliorative effects of dietary caloric
restriction on oxidative stress and inflammation in the brain of streptozotocin-induced diabetic
rats. Clinica Chimica Acta 370, 165-173. 7.
Ugochukwu, N.H. and Figgers C.L. (2006) Dietary caloric restriction modifies inflammatory
responses in the livers of streptozotocin-induced diabetic rats. Nutrition Research 26, 221-226.8.
Barber, K., Ugochukwu, N.H. and Figgers C.L. (2006) Dietary caloric restriction modulates
antioxidant capacity and dyslipidemia in the plasma of streptozotocin-induced diabetic rats.
McNair Journal 17: 8-15.9.
Ugochukwu, N. H., Bagayoko, N.D. and Antwi, M.E. (2004) The Effects of Dietary Caloric
Restriction on Antioxidant Status and lipid peroxidation in Mild and Severe Streptozotocin-
induced diabetic rats. Clinica Chimica Acta 348, 121 - 129.
2008 Florida Education Fund William R. Jones Mentor Award
2007 Florida Education Fund William R. Jones Most Valuable Mentor Award
2007 Florida A&M University Advanced Teacher of the Year Award
2006 Florida A & M University School of Graduate Studies Exemplary Mentor Award (College
of Arts & Sciences) for contributions to graduate education at FAMU.
2006 Ronald E. McNair Postbaccalaureate Achievement Program Certificate of Appreciation
for training students under the program.
2005 Florida A&M University Teacher of the Year Award
Mbuya, O. S., Ugochukwu, N.H. (Co-PI), Nzengung, V.A. and Jain, A. Phytoremediation of
perchlorate and N-nitrosodimethylamine as single and co-contaminants. A Research Project
funded by EPA/NCER Research Grant (2003 – 2006).2.
Pfizer Summer Undergraduate Research Fellowship Award on: The Effects of Dietary Caloric
Restriction on Oxidative Stress and Inflammation in the Brain of Streptozotocin-induced Diabetic
Rats (Mukes, Jessica - student) by Pfizer Groton Laboratories, Groton, Connecticut (Summer,
Mbuya, O. S. (P. I.); Ugochukwu, Ngozi H. (Co-P.I.) and Lowrance, R. (ARS Collaborator). Soil
Nitrate Below the Root Zone in Tomato Farms in North Florida. A Research Project funded by
the United States Department of Agriculture Cooperative Agreement Grant for the Center of
Excellence in Biology and Chemistry, Florida A & M University, Tallahassee (2002 – 2005).