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Thread: Synthesis and Biological Evaluation of some 1-octen-3-ol analogs as Mosquito Attractants

Created on: 04/17/10 01:57 PM

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Joined: 04/17/10

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Synthesis and Biological Evaluation
04/17/10 1:57 PM
Attachment: CESTA SRF Abstract FINAL.doc

Synthesis and Biological Evaluation of some 1-octen-3-ol analogs as Mosquito Attractants

Christianah A. Layodea, Osadolor Okungbowaa, Youcelyne Larosea, Edith Onyeozilia, Christopher O. Ikediobia, James Cilekc and Lekan Latinwob*
aDepartment of Chemistry and bBiology, Florida A&M University, 1530 S. Martin Luther King Jr. Blvd., Tallahassee, Florida 32307
cPublic Health Entomology Research & Education Center (PHEREC), Florida A&M University, Panama City, Florida 32405

Background: Mosquitoes are deadly vectors that transmit an array of viral diseases and as a result pose a significant threat to human health. Mosquito control depends solely on the use of insecticides and pesticides that are expensive, toxic, and environmentally harmful to humans, animals and plants. Hence, a solution to the hazardous effects of mosquito control would be an approach that is effective, economical, and environmentally friendly, with emphasis on eliminating mosquitoes by luring them into non-toxic traps where they are destroyed, thereby effectively reducing mosquito populations. Of the known mosquito attractants, 1-octen-3-ol has proven to be the most effective in general, though it attracts some mosquito species better than others. Purpose: Our work focuses on developing methods for the synthesis and biological investigation of more effective alkenol and alkynol analogs of 1-octen-3-ol that will attract a wider array of mosquito species. Methods: Syntheses are done via the reaction of a carbonyl group with a Grignard reagent to give alkenols, and the reduction of an alkynol to an alkenol. Biological investigation of alkenol and alkynol analogs is done in the field with relative temperature and humidity. Results: Successful synthesis of some alkenols and alkynols was achieved in good to excellent yields. Characterization was done via Infrared (IR) Spectroscopy, Gas Chromatography- Mass Spectrometry (GC-MS) and 1H Nuclear Magnetic Resonance (NMR) Spectroscopy. Field test investigation showed that some analogs of 1-octen-3-ol have better attractant properties than 1-octen-3-ol. Conclusion: Analogs of 1-octen-3-ol show great promise for mosquito control.

Acknowledgement: This work was supported by grant from the Florida A&M University College of Engineering Sciences, Technology and Agriculture Research & Extension Scholar Program
* Last updated by: clayode on 4/17/2010 @ 2:07 PM *

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